2025 NFL Odds Week 2: Lines, Spreads for all 16 Games

by MICHAELANTONIO

⭐️⭐️⭐️⭐️⭐️

After months of waiting, the first full Sunday of NFL football did not disappoint.

Week 2 is already underway after the Green Bay Packers’ 27-18 win over the Washington Commanders on Thursday night.


Here are the lines for every Week 2 matchup remaining at DraftKings Sportsbook as of Sept. 13.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

(All times ET)


2025 NFL Week 1 Odds

THURSDAY, SEPT. 11

PACKERS 27, COMMANDERS 18

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SUNDAY, SEPT. 14

JAGUARS @ BENGALS (1 p.m., CBS)

Point spread: Bengals -3.5 (Bengals favored to win by 3.5 points or more, otherwise Jaguars cover)
Moneyline: Bengals -180 favorites to win (bet $10 to win $15.56 total); Jaguars +150 underdogs to win (bet $10 to win $25 total)
Total Over/Under: 49.5 points scored by both teams combined

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GIANTS @ COWBOYS (1 p.m., FOX)

Point spread: Cowboys -4.5 (Cowboys favored to win by 4.5 points or more, otherwise Giants cover)
Moneyline: Cowboys -238 favorites to win (bet $10 to win $14.20 total); Giants +195 underdogs to win (bet $10 to win $29.50 total)
Total Over/Under: 44.5 points scored by both teams combined

BEARS @ LIONS (1 p.m., FOX)


Point spread: Lions -6.5 (Lions favored to win by 6.5 points or more, otherwise Bears cover)
Moneyline: Lions -285 favorites to win (bet $10 to win $13.51 total); Bears +230 underdogs to win (bet $10 to win $32.50 total)
Total Over/Under: 46.5 points scored by both teams combined

RAMS @ TITANS (1 p.m., CBS)

Point spread: Rams -5.5 (Rams favored to win by 5.5 points or more, otherwise Titans cover)
Moneyline: Rams -230 favorites to win (bet $10 to win $14.35 total); Titans +190 underdogs to win (bet $10 to win $29 total)
Total Over/Under: 41.5 points scored by both teams combined



PATRIOTS @ DOLPHINS (1 p.m., CBS)

Point spread: Dolphins -1.5 (Dolphins favored to win by 1.5 points or more, otherwise Patriots cover)
Moneyline: Dolphins -125 favorites to win (bet $10 to win $18 total); Patriots +105 underdogs to win (bet $10 to win $20.50 total)
Total Over/Under: 43.5 points scored by both teams combined

49ERS @ SAINTS (1 p.m., FOX)


Point spread: 49ers -3 (49ers favored to win by 3 points or more, otherwise Saints cover)
Moneyline: 49ers -166 favorites to win (bet $10 to win $16.02 total); Saints +140 underdogs to win (bet $10 to win $24 total)
Total Over/Under: 40.5 points scored by both teams combined

BILLS @ JETS (1 p.m., CBS)

Point spread: Bills -6.5 (Bills favored to win by 6.5 points or more, otherwise Jets cover)
Moneyline: Bills -305 favorites to win (bet $10 to win $13.28 total); Jets +245 underdogs to win (bet $10 to win $34 total)
Total Over/Under: 47.5 points scored by both teams combined


SEAHAWKS @ STEELERS (1 p.m., FOX)

Point spread: Steelers -3 (Steelers favored to win by 3 points or more, otherwise Seahawks cover)
Moneyline: Steelers -170 favorites to win (bet $10 to win $15.88 total); Seahawks +142 underdogs to win (bet $10 to win $24.20 total)
Total Over/Under: 40.5 points scored by both teams combined

BROWNS @ RAVENS (1 p.m., CBS)


Point spread: Ravens -11.5 (Ravens favored to win by 11.5 points or more, otherwise Browns cover)
Moneyline: Ravens -750 favorites to win (bet $10 to win $11.33 total); Browns +525 underdogs to win (bet $10 to win $62.50 total)
Total Over/Under: 45.5 points scored by both teams combined

BRONCOS @ COLTS (4:05 p.m., CBS)

Point spread: Broncos -2.5 (Broncos favored to win by 2.5 points or more, otherwise Colts cover)
Moneyline: Broncos -130 favorites to win (bet $10 to win $17.69 total); Colts +110 underdogs to win (bet $10 to win $21 total)
Total Over/Under: 43.5 points scored by both teams combined


PANTHERS @ CARDINALS (4:05 p.m., CBS)

Point spread: Cardinals -6.5 (Cardinals favored to win by 6.5 points or more, otherwise Panthers cover)
Moneyline: Cardinals -298 favorites to win (bet $10 to win $13.36 total); Panthers +240 underdogs to win (bet $10 to win $34 total)
Total Over/Under: 44.5 points scored by both teams combined

EAGLES @ CHIEFS (4:25 p.m., FOX)

Point spread: Eagles -1.5 (Eagles favored to win by 1.5 points or more, otherwise Chiefs cover)
Moneyline: Eagles -125 favorites to win (bet $10 to win $18 total); Chiefs +105 underdogs to win (bet $10 to win $20.50 total)
Total Over/Under: 46.5 points scored by both teams combined

FALCONS @ VIKINGS (8:20 p.m., NBC)

Point spread: Vikings -3.5 (Vikings favored to win by 3.5 points or more, otherwise Falcons cover)
Moneyline: Vikings -175 favorites to win (bet $10 to win $15.71 total); Falcons +145 underdogs to win (bet $10 to win $24.50 total)
Total Over/Under: 44.5 points scored by both teams combined

MONDAY, SEPT 15

BUCCANEERS @ TEXANS (7 p.m., ABC/ESPN)

Point spread: Texans -2.5 (Texans favored to win by 2.5 points or more, otherwise Buccaneers cover)
Moneyline: Texans -135 favorites to win (bet $10 to win $17.41 total); Buccaneers +114 underdogs to win (bet $10 to win $21.40 total)
Total Over/Under: 42.5 points scored by both teams combined

CHARGERS @ RAIDERS (10 p.m., ESPN)

Point spread: Chargers -3.5 (Chargers favored to win by 3.5 points or more, otherwise Raiders cover)
Moneyline: Chargers -185 favorites to win (bet $10 to win $15.41 total); Raiders +154 underdogs to win (bet $10 to win $25.40 total)
Total Over/Under: 46.5 points scored by both teams combined

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